Current research :

DNA/RNA purification matrix

Mutagenesis

Gene synthesis

Positional gene cloning

Mutation detection and SNP assay

Publications

	Chen LL, Zhang J, Peng CY, Liao DF, Li HJ, Gao HL, Li K	Related Articles,
	[Novel mechanism of 3' exonuclease of polymerase in maintenance of DNA replication fidelity and its application in SNP assay] Yi Chuan. 2005 Mar;27(2):279-83. Chinese. PMID: 15843359 [PubMed - in process]
	Lin-Ling C, Zhang J, Sommer SS, Li K.	Related Articles,
	Single-base discrimination mediated by proofreading inert allele specific Primers. J Biochem Mol Biol. 2005 Jan 31;38(1):24-7. PMID: 15715942 [PubMed - indexed for MEDLINE]
	Liao DF, Chen LL, Peng CY, Zhang J, Li K.	Related Articles,
	Exo+ proofreading polymerases mediate genetic analysis and its application in biomedical studies. Acta Pharmacol Sin. 2005 Mar;26(3):302-6. Review. PMID: 15715925 [PubMed - indexed for MEDLINE]
	Li K, Zhang J, Chen L, Sommer SS.	Related Articles,
	Superb nucleotide discrimination by a novel on/off switch for DNA polymerization and its applications. Mol Biotechnol. 2005 Feb;29(2):93-100. PMID: 15699566 [PubMed - indexed for MEDLINE]
	Zhang J, Li K, Pardinas JR, Sommer SS, Yao KT.	Related Articles,
	Proofreading genotyping assays mediated by high fidelity exo+ DNA polymerases. Trends Biotechnol. 2005 Feb;23(2):92-6. PMID: 15661346 [PubMed - in process]
	Zhang J, Li K.	Related Articles,
	New performance from an old member: SNP assay and de novo sequencing mediated by exo+ DNA polymerases. J Biochem Mol Biol. 2004 May 31;37(3):269-74. PMID: 15469706 [PubMed - indexed for MEDLINE]
	Zhang J, Li K, Pardinas JR, Liao DF, Li HJ, Zhang X	Related Articles,
	SNP discrimination through proofreading and OFF-switch of exo+ polymerase. Mol Biotechnol. 2004 May;27(1):75-80. Review. PMID: 15122048 [PubMed - indexed for MEDLINE]
	Zhang J, Li K.	Related Articles,
	Single-base discrimination mediated by proofreading 3' phosphorothioate-modified primers. Mol Biotechnol. 2003 Nov;25(3):223-8. PMID: 14668536 [PubMed - indexed for MEDLINE]
	Zhang J, Chen LL, Guo ZF, Peng CY, Liao DF, Li K.	Related Articles,
	On/off switch mediated by Exo+ polymerases: experimental analysis for its physiological and technological implications. J Biochem Mol Biol. 2003 Nov 30;36(6):529-32. PMID: 14659069 [PubMed - indexed for MEDLINE]
	Zhang J, Li K.	Related Articles,
	On-off regulation of 3' exonuclease excision to DNA polymerization by Exo+ polymerase. J Biochem Mol Biol. 2003 Nov 30;36(6):525-8. PMID: 14659068 [PubMed - indexed for MEDLINE]
	Zhang J, Meng B, Liao D, Zhou L, Zhang X, Chen L, Guo Z, Peng C, Zhu B, Lee PP, Xu X, Zhou T, Deng Z, Hu Y, Li K.	Related Articles,
	De novo synthesis of PCR templates for the development of SARS diagnostic assay. Mol Biotechnol. 2003 Oct;25(2):107-12. PMID: 14526121 [PubMed - indexed for MEDLINE]
	Zhang J, Li K, Liao D, Pardinas JR, Chen L, Zhang X.	Related Articles,
	Different applications of polymerases with and without proofreading activity in single-nucleotide polymorphism analysis. Lab Invest. 2003 Aug;83(8):1147-54. PMID: 12920243 [PubMed - indexed for MEDLINE]
	Guo ZF, Chen LL, Zhang J, Peng CY, Yang XD, Zhang X, He SY, Liao DF, Li K.	Related Articles,
	[Effect of 3' exonuclease activity of polymerase on extension of phosphorothioate-modified primers] Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Aug;20(4):328-30. Chinese. PMID: 12903045 [PubMed - in process]
	Zhang J, Li K, Deng Z, Liao D, Fang W, Zhang X.	Related Articles,
	Efficient mutagenesis method for producing the templates of single nucleotide polymorphisms. Mol Biotechnol. 2003 Jun;24(2):105-10. PMID: 12746551 [PubMed - indexed for MEDLINE]
	Li K, Zhang J.	Related Articles,
	ISIS-3521. Isis Pharmaceuticals. Curr Opin Investig Drugs. 2001 Oct;2(10):1454-61. Review. PMID: 11890365 [PubMed - indexed for MEDLINE]
	Li K, Zhang J, Sirois P, Hu Y.	Related Articles,
	Technology evaluation: ISIS-3521. Curr Opin Mol Ther. 1999 Jun;1(3):393-8. PMID: 11713804 [PubMed - indexed for MEDLINE]