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Mouse Anti-Human Axl Monoclonal Antibody (Clone #AB205) 200 ug AB205

{tab Description} Mouse Anti-Human Axl Monoclonal Antibody (Clone #AB205)  Mouse Anti-Human Axl Monoclonal Antibody (Clone #AB205)Catalog#: Quantity Lot#AB205 200 μg 0706Source: Hybridoma cell line was selected from a mouse myeloma fused with B cells obtained from a mouse immunized with purified ...Read more
$285.00 each

Product Code: AB205


  • Product Details

Description

Mouse Anti-Human Axl Monoclonal Antibody (Clone #AB205)

 Mouse Anti-Human Axl Monoclonal Antibody (Clone #AB205)
Catalog#: Quantity Lot#
AB205 200 μg 0706
Source: Hybridoma cell line was selected from a mouse myeloma fused with B cells obtained from a mouse immunized with purified recombinant human Axl extracellular domain. IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Formulation: Lyophilized powder lyophilized from phosphate-buffered saline (PBS)
Preservative: None.
Purity: >97% on 15% SDS-PAGE.
Sterility: 0.2 μm membrane-filtered and packaged aseptically.
QC Tests: SDS-PAGE, Western Blot, direct ELISA
Reconstitution and Use:
Reconstitute the contents of the vial using sterile phosphate-buffered saline (PBS) to a concentration no less than 100 μg/ml and aliquot for future use. (If the initial rehydration is too dilute, activity may be lost due to the non-specific adsorption to the container). The solution can then be further diluted to a working stock solution.
Storage and Stability:
Upon receiving, store the product at -20°C. After reconstitution, store the working aliquots at 2-8°C for no more than 3 months. For extended storage, aliquot the rehydrated solution (100 μg/ml) and freeze at -70°C or -20°C. Avoid repeated freezing and thawing. More dilute solutions stored at -20°C will lose activity faster.
About Axl:
Axl is coined from the Greek word "anexelekto", meaning out of control, also known as UFO or Ark. It is a type I transmembrane receptor tyrosine kinase with transforming activity. The extracellular domain contains two Ig-like motifs and two fibronectin type III motifs. It binds the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Recent studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions.